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Article

Mendelian randomization analysis to assess a causal effect of haptoglobin on macroangiopathy in Chinese type 2 diabetes patients.

Cardiovascular diabetology - 16 Jan 2018

Wang Shiyun, Wang Jie, Zhang Rong, Wang Tao, Yan Dandan, He Zhen, Jiang Feng, Hu Cheng, Jia Weiping

Abstract excerpt

BACKGROUND: Haptoglobin (Hp) functions as an antioxidant by binding with haemoglobin. We investigated whether serum Hp has a causal effect on macroangiopathy via Mendelian randomization (MR) analysis with common variants of the Hp gene in Chinese patients with type 2 diabetes. METHODS: A total of 5687 type 2 diabetes patients were recruited and genotyped for the Hp gene. Clinical features and vascular imaging...

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Identifiers

PMID: 29338727
DOI: 10.1186/s12933-018-0662-7
PMCID: PMC5769522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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