Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A 680 kb duplication at the FTO locus in a kindred with obesity and a distinct body fat distribution.

European journal of human genetics : EJHG - 1 Dec 2013

Davies Robert W, Lau Paulina, Naing Thet, Nikpay Majid, Doelle Heather, Harper Mary Ellen, Dent Robert, McPherson Ruth

Abstract excerpt

Common intronic SNPs in the human fat mass and obesity associated (FTO) gene are strongly associated with body mass index (BMI). In mouse models, inactivation of the Fto gene results in a lean phenotype, whereas overexpression of Fto leads to increased food intake and obesity. The latter finding suggests that copy number variants at the FTO locus might be associated with extremes of adiposity. To address this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Mass Index

Share to DNA Copy Number Variations

Share to Genome-Wide Association Study

Share to Obesity

Share to Proteins

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 23591406
DOI: 10.1038/ejhg.2013.63
PMCID: PMC3831078

Genes

FTO
RBL2
AKTIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A 680 kb duplication at the FTO locus in a kindred with obesity and a distinct body fat distribution.PMID 23591406Read ↗

Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children.Semantic proximity Read ↗

FTO: the first gene contributing to common forms of human obesity.Semantic proximity Read ↗

Investigation of a patient with a partial trisomy 16q including the fat mass and obesity associated gene (FTO): fine mapping and FTO gene expression study.Semantic proximity Read ↗

Large, rare chromosomal deletions associated with severe early-onset obesity.Semantic proximity Read ↗

Variation in FTO contributes to childhood obesity and severe adult obesity.Semantic proximity Read ↗

Prevalence of loss-of-function FTO mutations in lean and obese individuals.Semantic proximity Read ↗

FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs.Semantic proximity Read ↗

Complex Relationship between Obesity and the Fat Mass and Obesity Locus.Semantic proximity Read ↗

Progress in the genetics of common obesity: size mattersSemantic proximity Read ↗

Hypomorphism of Fto and Rpgrip1l causes obesity in mice.Semantic proximity Read ↗

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.Semantic proximity Read ↗

A genome-wide study reveals copy number variants exclusive to childhood obesity cases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.