Article
Hypertension and decreased aortic compliance due to reduced elastin amounts do not increase atherosclerotic plaque accumulation in Ldlr-/- mice.
Atherosclerosis - 1 Jun 2016
Maedeker Justine A, Stoka Kellie V, Bhayani Siddharth A, Gardner William S, Bennett Lisa, Procknow Jesse D, Staiculescu Marius C, Walji Tezin A, Craft Clarissa S, Wagenseil Jessica E
Abstract excerpt
BACKGROUND AND AIMS: High blood pressure and reduced aortic compliance are associated with increased atherosclerotic plaque accumulation in humans. Animal studies support these associations, but additional factors, such as fragmented elastic fibers, are present in most previous animal studies. Elastin heterozygous (Eln+/-) mice have high blood pressure and reduced aortic compliance, with no evidence of elastic...
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