Article

Prelamin A Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss

2025-09-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated aging disorder characterized by numerous symptoms, including early-onset atherosclerosis, with most patients suffering fatal myocardial infarctions or strokes by the second decade of life. HGPS is caused by mutations in LMNA that lead to expression of an internally truncated, farnesylated prelamin A variant calle...

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Literature Corpus work: 131e700b-d4e8-5bac-b647-b2e77a2745de
DOI: 10.1101/2025.09.15.676432

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