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Article

Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging.

Journal of hypertension - 1 Jul 2020

Spronck Bart, Ferruzzi Jacopo, Bellini Chiara, Caulk Alexander W, Murtada Sae-Il, Humphrey Jay D

Abstract excerpt

OBJECTIVES: Increased central artery stiffness associates with cardiovascular disease. Among other factors, hypertension and aging are strong contributors to central artery stiffening, yet it has been difficult to separate their effects. Herein, we study isolated and combined effects of hypertension and aging on central artery remodeling in multiple mouse models as a function of sex. METHODS: We biomechanically...

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Identifiers

PMID: 32068640
DOI: 10.1097/HJH.0000000000002400
PMCID: PMC7611466

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