Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient mice.

Abstract excerpt

Increased arterial stiffness and blood pressure are characteristic of humans and adult mice with reduced elastin levels caused by aging or genetic disease. Direct associations have been shown between increased arterial stiffness and hypertension in humans, but it is not known whether changes in mechanical properties or increased blood pressure occur first. Using genetically modified mice with elastin...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aorta
• Share to Carotid Arteries