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Article

A CRISPR-Based Toolbox for Studying T Cell Signal Transduction

1 Jan 2016

Abstract excerpt

CRISPR/Cas9 system is a powerful technology to perform genome editing in a variety of cell types. To facilitate the application of Cas9 in mapping T cell signaling pathways, we generated a toolbox for large-scale genetic screens in human Jurkat T cells. The toolbox has three different Jurkat cell lines expressing distinct Cas9 variants, including wild-type Cas9, dCas9-KRAB, and sunCas9. We demonstrated that the...

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PMID: 27057542
DOI: 10.1155/2016/5052369

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