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Detection of EGFR mutations in patients with suspected lung cancer using paired tissue-plasma testing: a prospective comparative study with plasma ddPCR assay.

Scientific reports - 28 Oct 2024

Shong Lynn Yim-Wah, Deng Jun-Yang, Kwok Hoi-Hin, Lee Nerissa Chui-Mei, Tseng Steven Cee-Zhung, Ng Lai-Yun, Yee Wilson Kwok-Sang, Lam David Chi-Leung

Abstract excerpt

Detecting EGFR mutations in plasma using droplet digital PCR (ddPCR) assay offers a promising diagnostic tool for lung cancer patients. The performance of plasma-based ddPCR assay relative to traditional EGFR mutation testing in tissue biopsies among Asian patients with suspected lung cancer remains underexplored. Consecutive patients admitted for diagnostic workup for suspected lung cancer were recruited....

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PMID: 39465302
DOI: 10.1038/s41598-024-76890-0
PMCID: PMC11514293

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