Article
Deceased-Donor Apolipoprotein L1 Renal-Risk Variants Have Minimal Effects on Liver Transplant Outcomes.
PloS one - 1 Jan 2016
Dorr Casey R, Freedman Barry I, Hicks Pamela J, Brown W Mark, Russell Gregory B, Julian Bruce A, Pastan Stephen O, Gautreaux Michael D, Muthusamy Amutha, Chinnakotla Srinath, Hauptfeld Vera, Bray Robert A, Kirk Allan D, Divers Jasmin, Israni Ajay K
Abstract excerpt
BACKGROUND: Apolipoprotein L1 gene (APOL1) G1 and G2 renal-risk variants, common in populations with recent African ancestry, are strongly associated with non-diabetic nephropathy, end-stage kidney disease, and shorter allograft survival in deceased-donor kidneys (autosomal recessive inheritance). Circulating APOL1 protein is synthesized primarily in the liver and hydrodynamic gene delivery of APOL1 G1 and G2...
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