Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.

doi:10.1186/s12916-016-0602-x

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Article

Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort.

BMC medicine - 4 Apr 2016

Bonilla Carolina, Lewis Sarah J, Martin Richard M, Donovan Jenny L, Hamdy Freddie C, Neal David E, Eeles Rosalind, Easton Doug, Kote-Jarai Zsofia, Al Olama Ali Amin, Benlloch Sara, Muir Kenneth, Giles Graham G, Wiklund Fredrik, Gronberg Henrik, Haiman Christopher A, Schleutker Johanna, Nordestgaard Børge G, Travis Ruth C, Pashayan Nora, Khaw Kay-Tee, Stanford Janet L, Blot William J, Thibodeau Stephen, Maier Christiane, Kibel Adam S, Cybulski Cezary, Cannon-Albright Lisa, Brenner Hermann, Park Jong, Kaneva Radka, Batra Jyotsna, Teixeira Manuel R, Pandha Hardev, Lathrop Mark, Davey Smith George

Abstract excerpt

BACKGROUND: Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates are likely to suffer from a degree of uncontrolled confounding. To obtain causal estimates, we examined the role of pubertal development in prostate cancer using genetic polymorphisms associated...

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PMID: 27044414
DOI: 10.1186/s12916-016-0602-x
PMCID: PMC4820939

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