Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin d and prostate cancer risk.

doi:10.1158/1055-9965.EPI-12-1248

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Article

Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin d and prostate cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2013

Bonilla Carolina, Gilbert Rebecca, Kemp John P, Timpson Nicholas J, Evans David M, Donovan Jenny L, Hamdy Freddie C, Neal David E, Fraser William D, Davey Smith George, Lewis Sarah J, Lathrop Mark, Martin Richard M

Abstract excerpt

BACKGROUND: Ecological and epidemiological studies have identified an inverse association of intensity and duration of sunlight exposure with prostate cancer, which may be explained by a reduction in vitamin D synthesis. Pigmentation traits influence sun exposure and therefore may affect prostate cancer risk. Because observational studies are vulnerable to confounding and measurement error, we used Mendelian...

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PMID: 23441100
DOI: 10.1158/1055-9965.EPI-12-1248
PMCID: PMC3616836

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