OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential.

doi:10.1158/1078-0432.CCR-15-2614

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2016

Lai Chester, August Suzannah, Albibas Amel, Behar Ramnik, Cho Shin-Young, Polak Marta E, Theaker Jeffrey, MacLeod Amanda S, French Ruth R, Glennie Martin J, Al-Shamkhani Aymen, Healy Eugene

Abstract excerpt

PURPOSE: Cutaneous squamous cell carcinoma (cSCC) is the most common human cancer with metastatic potential. Despite T cells accumulating around cSCCs, these tumors continue to grow and persist. To investigate reasons for failure of T cells to mount a protective response in cSCC, we focused on regulatory T cells (Tregs) as this suppressive population is well represented among the infiltrating lymphocytes....

Topics

Biomarkers
Carcinoma, Squamous Cell
Humans
Immunohistochemistry
Immunologic Memory
Immunomodulation
Immunophenotyping
Lymphocyte Activation
Lymphocyte Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes, Tumor-Infiltrating

Neoplasm Metastasis

Phenotype

Receptors, OX40

Skin Neoplasms

T-Lymphocyte Subsets

T-Lymphocytes, Regulatory

Source

Open in PubMed Open full text

Identifiers

PMID: 27034329
DOI: 10.1158/1078-0432.CCR-15-2614
PMCID: PMC4987192

Genes

CD4
FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential.PMID 27034329Read ↗

CD8+CD103+ tissue-resident memory T cells convey reduced protective immunity in cutaneous squamous cell carcinoma.Semantic proximity Read ↗

Decreased cytotoxic T cells and TCR clonality in organ transplant recipients with squamous cell carcinomaSemantic proximity Read ↗

Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8+ T Cells co-expressing PD-1 and LAG-3 inhibitory receptors.Semantic proximity Read ↗

Immunosuppression Affects CD4+ mRNA Expression and Induces Th2 Dominance in the Microenvironment of Cutaneous Squamous Cell Carcinoma in Organ Transplant RecipientsSemantic proximity Read ↗

The pattern and clinicopathological correlates of programmed death-ligand 1 expression in cutaneous squamous cell carcinomaSemantic proximity Read ↗

Immune phenotype predicts risk for posttransplantation squamous cell carcinoma.Semantic proximity Read ↗

Immune-Checkpoint Blockade Opposes CD8+ T-cell Suppression in Human and Murine CancerSemantic proximity Read ↗

Comparative immune phenotypic analysis of cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in immune-competent individuals: proportional representation of CD8+ T-cells but not FoxP3+ Regulatory T-cells is associated with disease stage.Semantic proximity Read ↗

Cancer-Testis Antigens and Immunosurveillance in Human Cutaneous Squamous Cell and Basal Cell CarcinomasSemantic proximity Read ↗

The microenvironment in primary cutaneous melanoma with associated spontaneous tumor regression: evaluation for T-regulatory cells and the presence of an immunosuppressive microenvironment.Semantic proximity Read ↗

The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.Semantic proximity Read ↗

Association of the numbers of CD163(+) cells in lesional skin and serum levels of soluble CD163 with disease progression of cutaneous T cell lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.