Article
Association of the numbers of CD163(+) cells in lesional skin and serum levels of soluble CD163 with disease progression of cutaneous T cell lymphoma.
Journal of dermatological science - 1 Oct 2012
Sugaya Makoto, Miyagaki Tomomitsu, Ohmatsu Hanako, Suga Hiraku, Kai Hiromichi, Kamata Masahiro, Fujita Hideki, Asano Yoshihide, Tada Yayoi, Kadono Takafumi, Okochi Hitoshi, Sato Shinichi
Abstract excerpt
BACKGROUND: Classically activated macrophages produce IL-12, IL-23, and TNF-α, whereas alternatively activated macrophages (M2 cells) produce IL-10 and express several receptors such as mannose receptor and CD163. Tumor-associated macrophages exhibit M2 phenotype, whose presence has been associated with poor prognosis in various tumors. OBJECTIVES: To investigate distribution of CD163(+) cells in lesional skin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
