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Article

A GABBR2 gene variant modifies pathophysiology in Huntington's disease.

Neuroscience letters - 4 May 2016

Philpott April L, Fitzgerald Paul B, Bailey Neil W, Churchyard Andrew, Georgiou-Karistianis Nellie, Cummins Tarrant D R

Abstract excerpt

Striatal degeneration in Huntington's disease (HD) causes changes in cortico-subcortical pathways. Transcranial magnetic stimulation (TMS) is a valuable tool for assessing pathophysiology within these pathways, yet has had limited application in HD. As cortico-subcortical pathways are largely mediated by GABA and dopamine receptor genes, understanding how these genes modulate neurophysiology in HD may provide new...

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Source

Identifiers

PMID: 27033668
DOI: 10.1016/j.neulet.2016.03.038

Genes

GABBR2
DRD2
GABRA2
DRD1
DRD4
GABBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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