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Article

Ovarian cancer stem-like cells differentiate into endothelial cells and participate in tumor angiogenesis through autocrine CCL5 signaling.

Cancer letters - 28 Jun 2016

Tang Shu, Xiang Tong, Huang Shuo, Zhou Jie, Wang Zhongyu, Xie Rongkai, Long Haixia, Zhu Bo

Abstract excerpt

Cancer stem cells (CSCs) are well known for their self-regeneration and tumorigenesis potential. In addition, the multi-differentiation potential of CSCs has become a popular issue and continues to attract increased research attention. Recent studies demonstrated that CSCs are able to differentiate into functional endothelial cells and participate in tumor angiogenesis. In this study, we found that ovarian cancer...

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Share to Autocrine Communication
Share to Cell Transdifferentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CCL5

Share to Heterografts

Share to Human Umbilical Vein Endothelial Cells

Share to Neovascularization, Pathologic

Share to Receptors, CCR5

Share to STAT3 Transcription Factor

Source

Identifiers

PMID: 27033454
DOI: 10.1016/j.canlet.2016.03.034

Genes

CCL5
CCR1
CCR3
CCR5
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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