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Article

CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells.

Cancer research - 1 Jun 2012

Tsuyada Akihiro, Chow Amy, Wu Jun, Somlo George, Chu Peiguo, Loera Sofia, Luu Thehang, Li Arthur Xuejun, Wu Xiwei, Ye Wei, Chen Shiuan, Zhou Weiying, Yu Yang, Wang Yuan-Zhong, Ren Xiubao, Li Hui, Scherle Peggy, Kuroki Yukio, Wang Shizhen Emily

Abstract excerpt

Cancer stem cells (CSC) play critical roles in cancer initiation, progression, and therapeutic refractoriness. Although many studies have focused on the genes and pathways involved in stemness, characterization of the factors in the tumor microenvironment that regulate CSCs is lacking. In this study, we investigated the effects of stromal fibroblasts on breast cancer stem cells. We found that compared with normal...

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Source

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Identifiers

PMID: 22472119
DOI: 10.1158/0008-5472.CAN-11-3567
PMCID: PMC3367125

Genes

CCL2
NOTCH1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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