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Article

KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles.

Scientific reports - 31 Mar 2016

Bari Rafijul, Thapa Rajoo, Bao Ju, Li Ying, Zheng Jie, Leung Wing

Abstract excerpt

KIR2DL2 and KIR2DL3 segregate as alleles of a single locus in the centromeric motif of the killer cell immunoglobulin-like receptor (KIR) gene family. Although KIR2DL2/L3 polymorphism is known to be associated with many human diseases and is an important factor for donor selection in allogeneic hematopoietic stem cell transplantation, the molecular determinant of functional diversity among various alleles is...

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PMID: 27030405
DOI: 10.1038/srep23689
PMCID: PMC4814820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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KIR2DL2/2DL3-E(35) alleles are functionally stronger than -Q(35) alleles.PMID 27030405Read ↗

Synergistic polymorphism at two positions distal to the ligand-binding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3.Semantic proximity Read ↗

Allelic variation in KIR2DL3 generates a KIR2DL2-like receptor with increased binding to its HLA-C ligand.Semantic proximity Read ↗

Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.Semantic proximity Read ↗

Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: identification of the amino acid residues critical for staining.Semantic proximity Read ↗

[Analysis of KIR3DL1 expression levels on 92 cases of normal donors for hematopoietic stem cells transplant].Semantic proximity Read ↗

KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.Semantic proximity Read ↗

Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity.Semantic proximity Read ↗

Natural variation at position 45 in the D1 domain of lineage III killer cell immunoglobulin-like receptors (KIR) has major effects on the avidity and specificity for MHC class I.Semantic proximity Read ↗

Large spectrum of HLA-C recognition by killer Ig-like receptor (KIR)2DL2 and KIR2DL3 and restricted C1 SPECIFICITY of KIR2DS2: dominant impact of KIR2DL2/KIR2DS2 on KIR2D NK cell repertoire formation.Semantic proximity Read ↗

Conserved KIR allele-level haplotypes are altered by microvariation in individuals with European ancestry.Semantic proximity Read ↗

Co-evolution of KIR2DL3 with HLA-C in a human population retaining minimal essential diversity of KIR and HLA class I ligands.Semantic proximity Read ↗

Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of arginine 245.Semantic proximity Read ↗

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