Sequence Evolution Under Constraints: Lessons Learned from Sudoku.

Abstract excerpt

The complex structures of all proteins in nature are outcomes of a random walk driven by mutation and selection. Reconstructing the fitness landscape staging this process based on first-principle physical rules or experimental measurements is difficult. In this article we turn the popular Sudoku game into an artificial fitness landscape and use it as a model system to study sequence evolution under constraints....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computer Simulation
• Share to Evolution, Molecular
• Share to Gene Duplication