Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Size scaling of mutation avalanches in a model for protein evolution.

Journal of theoretical biology - 21 Mar 2003

Nikolic Djordje L, Lacks Daniel J

Abstract excerpt

The tunably rugged NK-model is used to study avalanche-like events that occur when environmental change causes fitness optima to disappear. The probability of an event with Delta substitutions scales as exp(-c Delta) for smooth landscapes, and as exp(-c Delta(2)) for rugged landscapes. Increasing the ruggedness leads to two competing effects: (1) more possible routes by which single mutations can increase the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Computer Simulation
Share to Environment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Models, Genetic

Share to Mutation

Share to Proteins

Source

Identifiers

PMID: 12628232
DOI: 10.1006/jtbi.2003.3188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Size scaling of mutation avalanches in a model for protein evolution.PMID 12628232Read ↗

Sequence Evolution Under Constraints: Lessons Learned from Sudoku.Semantic proximity Read ↗

Universal distribution of protein evolution rates as a consequence of protein folding physics.Semantic proximity Read ↗

Predictability of evolutionary trajectories in fitness landscapes.Semantic proximity Read ↗

Comparing folding codes in simple heteropolymer models of protein evolutionary landscape: robustness of the superfunnel paradigm.Semantic proximity Read ↗

Experimental rugged fitness landscape in protein sequence space.Semantic proximity Read ↗

Thermodynamics of neutral protein evolution.Semantic proximity Read ↗

Protein stability imposes limits on organism complexity and speed of molecular evolution.Semantic proximity Read ↗

Neutral evolution of proteins: The superfunnel in sequence space and its relation to mutational robustness.Semantic proximity Read ↗

Gene Conversion Facilitates Adaptive Evolution on Rugged Fitness Landscapes.Semantic proximity Read ↗

Role of random genetic drift in the evolution of interactive systems.Semantic proximity Read ↗

Adaptive walks with noisy fitness measurements.Semantic proximity Read ↗

Determinants of simulated RNA evolution.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.