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Article

Assessment of thiopurine S-methyltransferase activity in patients prescribed thiopurines: a systematic review.

Annals of internal medicine - 21 Jun 2011

Booth Ronald A, Ansari Mohammed T, Loit Evelin, Tricco Andrea C, Weeks Laura, Doucette Steve, Skidmore Becky, Sears Margaret, Sy Richmond, Karsh Jacob

Abstract excerpt

BACKGROUND: The evidence for testing thiopurine S-methyltransferase (TPMT) enzymatic activity or genotype before starting therapy with thiopurine-based drugs is unclear. PURPOSE: To examine the sensitivity and specificity of TPMT genotyping for TPMT enzymatic activity, reducing harm from thiopurine by pretesting, and the association of thiopurine toxicity with TPMT status in adults and children with chronic...

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Source

Identifiers

PMID: 21690596
DOI: 10.7326/0003-4819-154-12-201106210-00009

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Assessment of thiopurine S-methyltransferase activity in patients prescribed thiopurines: a systematic review.PMID 21690596Read ↗

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