Article

Optimizing nucleic acid extraction and transcriptome evaluation from low-input, fixed clinical samples

2020-06-03

Abstract excerpt

Tumor biopsies are commonly formalin-fixed and paraffin-embedded (FFPE) for long-term and efficient storage. However, FFPE preservation can greatly compromise the quality of samples, the extraction of nucleic acids, and feasibility of downstream studies, including RNA sequencing. These challenges are especially evident in the studies of clinical trial samples, where the sizes of biopsies often limit the amount of...

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Literature Corpus work: 6dbf5c09-d0ab-5679-9eed-12805f5cc6ac
DOI: 10.1101/2020.06.02.122150

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