Article
Loss of B cells and their precursors is the most constant feature of GATA-2 deficiency in childhood myelodysplastic syndrome.
Haematologica - 1 Jun 2016
Nováková Michaela, Žaliová Markéta, Suková Martina, Wlodarski Marcin, Janda Aleš, Froňková Eva, Campr Vít, Lejhancová Kateřina, Zapletal Ondřej, Pospíšilová Dagmar, Černá Zdeňka, Kuhn Tomáš, Švec Peter, Pelková Vendula, Zemanová Zuzana, Kerndrup Gitte, van den Heuvel-Eibrink Marry, van der Velden Vincent, Niemeyer Charlotte, Kalina Tomáš, Trka Jan, Starý Jan, Hrušák Ondřej, Mejstříková Ester
Abstract excerpt
GATA-2 deficiency was recently described as common cause of overlapping syndromes of immunodeficiency, lymphedema, familiar myelodysplastic syndrome or acute myeloid leukemia. The aim of our study was to analyze bone marrow and peripheral blood samples of children with myelodysplastic syndrome or aplastic anemia to define prevalence of the GATA2 mutation and to assess whether mutations in GATA-2 transcription...
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