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Article

Evolutionary Conserved Positions Define Protein Conformational Diversity.

PLoS computational biology - 1 Mar 2016

Saldaño Tadeo E, Monzon Alexander M, Parisi Gustavo, Fernandez-Alberti Sebastian

Abstract excerpt

Conformational diversity of the native state plays a central role in modulating protein function. The selection paradigm sustains that different ligands shift the conformational equilibrium through their binding to highest-affinity conformers. Intramolecular vibrational dynamics associated to each conformation should guarantee conformational transitions, which due to its importance, could possibly be associated...

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Identifiers

PMID: 27008419
DOI: 10.1371/journal.pcbi.1004775
PMCID: PMC4805271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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