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Article

Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.

Blood - 8 Aug 2013

Ren Mingqiang, Qin Haiyan, Kitamura Eiko, Cowell John K

Abstract excerpt

Myeloid and lymphoid neoplasm associated with FGFR1 is an aggressive disease, and resistant to all the current chemotherapies. To define the molecular etiology of this disease, we have developed murine models of this disease, in syngeneic hosts as well as in nonobese diabetic/severe combined immunodeficiency/interleukin 2Rγ(null) mice engrafted with transformed human CD34+ hematopoietic stem/progenitor cells....

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Topics

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Share to Antigens, CD34
Share to Gene Library
Share to Immunoglobulins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, T-Cell

Share to Myeloproliferative Disorders

Share to Proto-Oncogene Proteins c-kit

Share to Proto-Oncogene Proteins c-myc

Share to Receptor, Fibroblast Growth Factor, Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 23777766
DOI: 10.1182/blood-2013-03-489823
PMCID: PMC3739028

Genes

FGFR1
CNTRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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