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Article

Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance.

BMC medicine - 23 Mar 2016

Phelan Jody, Coll Francesc, McNerney Ruth, Ascher David B, Pires Douglas E V, Furnham Nick, Coeck Nele, Hill-Cawthorne Grant A, Nair Mridul B, Mallard Kim, Ramsay Andrew, Campino Susana, Hibberd Martin L, Pain Arnab, Rigouts Leen, Clark Taane G

Abstract excerpt

BACKGROUND: Combating the spread of drug resistant tuberculosis is a global health priority. Whole genome association studies are being applied to identify genetic determinants of resistance to anti-tuberculosis drugs. Protein structure and interaction modelling are used to understand the functional effects of putative mutations and provide insight into the molecular mechanisms leading to resistance. METHODS: To...

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Share to Drug Resistance, Multiple, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27005572
DOI: 10.1186/s12916-016-0575-9
PMCID: PMC4804620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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