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Article

Reduced DNA methylation patterning and transcriptional connectivity define human skin aging

23 Mar 2016

Abstract excerpt

Epigenetic changes represent an attractive mechanism for understanding the phenotypic changes associated with human aging. Age-related changes in DNA methylation at the genome scale have been termed 'epigenetic drift', but the defining features of this phenomenon remain to be established. Human epidermis represents an excellent model for understanding age-related epigenetic changes because of its substantial...

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Share to Circadian rhythm and melatonin
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PMID: 27004597
DOI: 10.1111/acel.12470

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