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Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin

27 May 2010

Abstract excerpt

Epigenetic changes are widely considered to play an important role in aging, but experimental evidence to support this hypothesis has been scarce. We have used array-based analysis to determine genome-scale DNA methylation patterns from human skin samples and to investigate the effects of aging, chronic sun exposure, and tissue variation. Our results reveal a high degree of tissue specificity in the methylation...

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Epigenetics and DNA Methylation
Genomics and Chromatin Dynamics
Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 20523906
DOI: 10.1371/journal.pgen.1000971

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