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Article

The deletion mutant EGFRvIII significantly contributes to stress resistance typical for the tumour microenvironment.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Sept 2009

Theys Jan, Jutten Barry, Dubois Ludwig, Rouschop Kasper M A, Chiu Roland K, Li Younan, Paesmans Kim, Lambin Philippe, Lammering Guido, Wouters Bradly G

Abstract excerpt

BACKGROUND AND PURPOSE: The epidermal growth factor receptor (EGFR) is overexpressed or mutated in many tumour types. The truncated, constitutively active EGFRvIII variant has not been detected in normal tissues but is found in many malignancies. In the current study, we have investigated the hypothesis that EGFRvIII contributes to a growth and survival advantage under tumour microenvironment-related stress...

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Source

Identifiers

PMID: 19616331
DOI: 10.1016/j.radonc.2009.06.017

Genes

EGFR

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