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Article

Variants in SULT2A1 affect the DHEA sulphate to DHEA ratio in patients with polycystic ovary syndrome but not the hyperandrogenic phenotype.

The Journal of clinical endocrinology and metabolism - 1 Sept 2013

Louwers Yvonne V, de Jong Frank H, van Herwaarden Nathalie A A, Stolk Lisette, Fauser Bart C J M, Uitterlinden André G, Laven Joop S E

Abstract excerpt

CONTEXT: Because of the elevated dehydroepiandrosterone sulfate (DHEAS) levels in polycystic ovary syndrome (PCOS) and the heritability of DHEAS serum levels, genes encoding the enzymes that control the sulfation of dehydroepiandrosterone (DHEA) to DHEAS and vice versa are obvious candidate genes to explain part of the heritability of PCOS. OBJECTIVE: The objective of the study was to determine the role of...

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Source

Identifiers

PMID: 23861462
DOI: 10.1210/jc.2013-1976

Genes

PAPSS2
STS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variants in SULT2A1 affect the DHEA sulphate to DHEA ratio in patients with polycystic ovary syndrome but not the hyperandrogenic phenotype.PMID 23861462Read ↗

Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome.Semantic proximity Read ↗

A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio.Semantic proximity Read ↗

Effects of genetic polymorphisms on the sulfation of dehydroepiandrosterone and pregnenolone by human cytosolic sulfotransferase SULT2A1.Semantic proximity Read ↗

PAPSS2 deficiency causes androgen excess via impaired DHEA sulfation--in vitro and in vivo studies in a family harboring two novel PAPSS2 mutations.Semantic proximity Read ↗

Association between human SHBG gene polymorphisms and risk of PCOS: a meta-analysis.Semantic proximity Read ↗

Impact of Genetic Polymorphisms on the Sulfation of Dehydroepiandrosterone and 17-β estradiol by Human Cytosolic Sulfotransferase SULT2B1aSemantic proximity Read ↗

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Human sulfotransferase SULT2A1 pharmacogenetics: genotype-to-phenotype studies.Semantic proximity Read ↗

Impact of genetic polymorphisms on the sulfation of dehydroepiandrosterone and 17-β estradiol by human cytosolic sulfotransferase SULT2B1a.Semantic proximity Read ↗

Impact of Genetic Polymorphisms on the Sulfation of Dehydroepiandrosterone and 17-β Estradiol by Human Cytosolic Sulfotransferase SULT2B1aSemantic proximity Read ↗

The role of genetic polymorphisms in the sulfation of pregnenolone by human cytosolic sulfotransferase SULT2B1aSemantic proximity Read ↗

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