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Article

Effects of genetic risk for alcohol dependence and onset of regular drinking on the progression to alcohol dependence: A polygenic risk score approach.

Drug and alcohol dependence - 1 Jan 2022

Yeung Ellen W, Spychala Kellyn M, Miller Alex P, Otto Jacqueline M, Deak Joseph D, Kim Hanjoe, Gilder David A, Ehlers Cindy L, Wilhelmsen Kirk C, Gizer Ian R

Abstract excerpt

BACKGROUND: Prior studies have established the importance of genetic contributions to the etiology of alcohol dependence (AD), and suggested an early onset of alcohol use represents an initial marker of this genetic risk, which is associated with a more rapid progression to AD and increased risk for AD itself. Building on prior work, the current study examined whether the additive effects of AD risk variants...

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Identifiers

PMID: 34844060
DOI: 10.1016/j.drugalcdep.2021.109117
PMCID: PMC8714681

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