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Article

Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.

Pharmacogenetics and genomics - 1 Oct 2012

Frazier-Wood Alexis C, Aslibekyan Stella, Borecki Ingrid B, Hopkins Paul N, Lai Chao-Qiang, Ordovas Jose M, Straka Robert J, Tiwari Hemant K, Arnett Donna K

Abstract excerpt

OBJECTIVE: A shift towards overall larger very low-density lipoprotein (VLDL), and smaller low-density lipoprotein and high-density lipoprotein (HDL) diameters occurs in insulin resistance (IR), which reflects shifts in the distribution of the subfraction concentrations. Fenofibrate, indicated for hypertriglyceridemia, simultaneously reduces IR and shifts in lipoprotein diameter. Individual responses to...

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Identifiers

PMID: 22890011
DOI: 10.1097/FPC.0b013e328357f6af
PMCID: PMC3760420

Genes

AHCYL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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