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Article

Identification of SHANK2 Pathogenic Variants in a Chinese Uygur Population with Schizophrenia.

Journal of molecular neuroscience : MN - 1 Jan 2021

Zhang Han, Wang Dong, Chen Jianhua, Li Xiuli, Yi Qizhong, Shi Yongyong

Abstract excerpt

Genomic studies on schizophrenia (SCZ) have revealed several candidate genes involved in excitatory synapse function and plasticity associated with its etiology. SHANK2 is a postsynaptic scaffolding protein, which anchors a protein complex connecting NMDAR, AMPAR, and mGluR receptors at excitatory neuronal synapses. Mutations in the SHANK2 gene have been reported to be associated with human autism spectrum...

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PMID: 32897530
DOI: 10.1007/s12031-020-01606-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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