Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma.

doi:10.1158/0008-5472.CAN-18-0527

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Article

Patient-Derived Xenograft Models Reveal Intratumor Heterogeneity and Temporal Stability in Neuroblastoma.

Cancer research - 15 Oct 2018

Braekeveldt Noémie, von Stedingk Kristoffer, Fransson Susanne, Martinez-Monleon Angela, Lindgren David, Axelson Håkan, Levander Fredrik, Willforss Jakob, Hansson Karin, Øra Ingrid, Backman Torbjörn, Börjesson Anna, Beckman Siv, Esfandyari Javanshir, Berbegall Ana P, Noguera Rosa, Karlsson Jenny, Koster Jan, Martinsson Tommy, Gisselsson David, Påhlman Sven, Bexell Daniel

Abstract excerpt

Patient-derived xenografts (PDX) and the Avatar, a single PDX mirroring an individual patient, are emerging tools in preclinical cancer research. However, the consequences of intratumor heterogeneity for PDX modeling of biomarkers, target identification, and treatment decisions remain underexplored. In this study, we undertook serial passaging and comprehensive molecular analysis of neuroblastoma orthotopic PDXs,...

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PMID: 30154149
DOI: 10.1158/0008-5472.CAN-18-0527

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