Elucidating the genotype-phenotype map by automatic enumeration and analysis of the phenotypic repertoire.

Abstract excerpt

BACKGROUND: The gap between genotype and phenotype is filled by complex biochemical systems most of which are poorly understood. Because these systems are complex, it is widely appreciated that quantitative understanding can only be achieved with the aid of mathematical models. However, formulating models and measuring or estimating their numerous rate constants and binding constants is daunting. Here we present...

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