Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Automated construction and analysis of the design space for biochemical systems.

Bioinformatics (Oxford, England) - 15 Oct 2010

Fasani Rick A, Savageau Michael A

Abstract excerpt

MOTIVATION: Our recent work introduced a generic method to construct the design space of biochemical systems: a representation of the relationships between system parameters, environmental variables and phenotypic behavior. In design space, the qualitatively distinct phenotypes of a biochemical system can be identified, counted, analyzed and compared. Boundaries in design space indicate a transition between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Automation
Share to Biochemical Phenomena
Share to Computational Biology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Biological

Share to Phenotype

Share to Systems Biology

Source

Open in PubMed Open full text

Identifiers

PMID: 20823298
DOI: 10.1093/bioinformatics/btq479
PMCID: PMC3025649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Automated construction and analysis of the design space for biochemical systems.PMID 20823298Read ↗

Phenotypes and tolerances in the design space of biochemical systems.Semantic proximity Read ↗

Biomedical engineering strategies in system design space.Semantic proximity Read ↗

Qualitatively distinct phenotypes in the design space of biochemical systems.Semantic proximity Read ↗

Elucidating the genotype-phenotype map by automatic enumeration and analysis of the phenotypic repertoire.Semantic proximity Read ↗

Phenotype Design Space Provides a Mechanistic Framework Relating Molecular Parameters to Phenotype Diversity Available for Selection.Semantic proximity Read ↗

Rational strain design with minimal phenotype perturbation.Semantic proximity Read ↗

GAMES: A dynamic model development workflow for rigorous characterization of synthetic genetic systemsSemantic proximity Read ↗

Phenotypic deconstruction of gene circuitry.Semantic proximity Read ↗

Optimization and model reduction in the high dimensional parameter space of a budding yeast cell cycle model.Semantic proximity Read ↗

Performing selections under dynamic conditions for synthetic biology applications.Semantic proximity Read ↗

Understanding biochemical design principles with ensembles of canonical non-linear models.Semantic proximity Read ↗

Phenotype-centric modeling for rational metabolic engineering.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.