Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice

13 Mar 2018

Abstract excerpt

H5N6 avian influenza viruses (AIVs) can cause severe pneumonia and death in humans. However, the molecular determinants of H5N6 influenza virus mammalian adaption are still unclear. Three amino acid substitutions (HA A150V, PA A343T, PB2 E627K) are observed in H5N6 virus A/duck/Zhejiang/6D2/2013 (6D2) in lung-to-lung passage in mice. These substitutions are crucial to the pathogenicity of mouse-adapted virus. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to Influenza Virus Research Studies
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29593694
DOI: 10.3389/fmicb.2018.00453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in MicePMID 29593694Read ↗

Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian AdaptationSemantic proximity Read ↗

Mouse adaptation of H6 avian influenza viruses and their molecular characteristicsSemantic proximity Read ↗

A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in MiceSemantic proximity Read ↗

A Combination of HA and PA Mutations Enhances Virulence in a Mouse-Adapted H6N6 Influenza A VirusSemantic proximity Read ↗

Immediate PB2-E627K amino acid substitution after single infection of highly pathogenic avian influenza H5N1 clade 2.3.4.4b in miceSemantic proximity Read ↗

Exploring the alternative virulence determinants PB2 S155N and PA S49Y/D347G that promote mammalian adaptation of the H9N2 avian influenza virus in miceSemantic proximity Read ↗

Mutual antagonism of mouse-adaptation mutations in HA and PA proteins on H9N2 virus replication.Semantic proximity Read ↗

Amino acid substitutions occurring during adaptation of an emergent H5N6 avian influenza virus to mammals.Semantic proximity Read ↗

Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice.Semantic proximity Read ↗

Enhanced pathogenicity and transmissibility of H9N2 avian influenza virus in mammals by hemagglutinin mutations combined with PB2-627K.Semantic proximity Read ↗

Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus.Semantic proximity Read ↗

Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.