Article
Treating psoriasis by targeting its susceptibility gene Rel.
Clinical immunology (Orlando, Fla.) - 1 Apr 2016
Fan Tingting, Wang Shaowen, Yu Linjiang, Yi Huqiang, Liu Ruiling, Geng Wenwen, Wan Xiaochun, Ma Yifan, Cai Lintao, Chen Youhai H, Ruan Qingguo
Abstract excerpt
Psoriasis is a chronic inflammatory disorder of the skin. Accumulating evidence indicates that the Rel gene, a member of the NF-κB family, is a risk factor for the disease. We sought to investigate whether psoriasis can be prevented by directly targeting the Rel gene transcript, i.e., the c-Rel mRNA. Using chemically-modified c-Rel specific siRNA (siRel) and poly(ethylene...
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