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Article

Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3.

Investigative ophthalmology & visual science - 1 Jul 2008

Janssen Andreas, Hoellenriegel Julia, Fogarasi Marton, Schrewe Heinrich, Seeliger Mathias, Tamm Ernst, Ohlmann Andreas, May Christian Albrecht, Weber Bernhard H F, Stöhr Heidi

Abstract excerpt

PURPOSE: Tissue inhibitor of metalloprotease (TIMP)-3 is an inhibitor of matrix metalloprotease (MMP) and regulates angiogenesis. In the eye, TIMP3 is tightly associated with Bruch's membrane. In this study, the authors analyzed mice lacking TIMP3 for retinal abnormalities. METHODS: Mice with targeted disruption of the Timp3 gene were generated (Timp3(-/-)) and bred into C57/Bl6 and CD1 backgrounds. Eyes were...

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Source

Identifiers

PMID: 18408187
DOI: 10.1167/iovs.07-1444

Genes

TIMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3.PMID 18408187Read ↗

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