Article
Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: gene-environment interaction.
Carcinogenesis - 1 Jun 2016
Masaoka Hiroyuki, Ito Hidemi, Soga Norihito, Hosono Satoyo, Oze Isao, Watanabe Miki, Tanaka Hideo, Yokomizo Akira, Hayashi Norio, Eto Masatoshi, Matsuo Keitaro
Abstract excerpt
Although a range of chemical exposures (cigarette smoking and occupational exposure) are recognized risk factors for the development of bladder cancer (BCa), many epidemiological studies have demonstrated that alcohol drinking is not associated with BCa risk. Aldehyde dehydrogenase 2 (ALDH2; rs671, Glu504Lys) and alcohol dehydrogenase 1B (ADH1B; rs1229984, His47Arg) polymorphisms impact the accumulation of...
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