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Article

Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2000

Yang Chun-Xia, Matsuo Keitaro, Ito Hidemi, Hirose Kaoru, Wakai Kenji, Saito Toshiko, Shinoda Masayuki, Hatooka Shunzo, Mizutani Kazuko, Tajima Kazuo

Abstract excerpt

Alcohol drinking is a major risk factor for esophageal cancer in Japan and its impact may be modulated by levels of ALDH2, ADH2 and CYP2E1, three representative alcohol-metabolizing enzymes which display genetic polymorphisms altering individual alcohol-oxidizing capacity and drinking behavior. To assess the actual influence of ADH2 Arg47His, ALDH2 Glu487Lys and CYP2E1 variant c2 allele polymorphisms on...

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Source

Identifiers

PMID: 16235983

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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