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Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males.

World journal of gastroenterology - 28 Aug 2008

Gao Chang-Ming, Takezaki Toshiro, Wu Jian-Zhong, Zhang Xiao-Mei, Cao Hai-Xia, Ding Jian-Hua, Liu Yan-Ting, Li Su-Ping, Cao Jia, Matsuo Keitaro, Hamajima Nobuyuki, Tajima Kazuo

Abstract excerpt

AIM: To evaluate the relationship between drinking and polymorphisms of alcohol dehydrogenase 2 (ADH2) and/or aldehyde dehydrogenase 2 (ALDH2) for risk of colorectal cancer (CRC) in Chinese males. METHODS: A case-control study was conducted in 190 cases and 223 population-based controls. ADH2 Arg47His (G-A) and ALDH2 Glu487Lys (G-A) genotypes were identified by PCR and denaturing high-performance liquid...

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Source

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Identifiers

PMID: 18763293
DOI: 10.3748/wjg.14.5078
PMCID: PMC2742938

Genes

ALDH2

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