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Article

BRAF, PIK3CA, and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal Cancers with Distant Metastasis.

PloS one - 1 Jan 2016

Nam Soo Kyung, Yun Sumi, Koh Jiwon, Kwak Yoonjin, Seo An Na, Park Kyoung Un, Kim Duck-Woo, Kang Sung-Bum, Kim Woo Ho, Lee Hye Seung

Abstract excerpt

BACKGROUND: Anti-EGFR antibody-based treatment is an important therapeutic strategy for advanced colorectal cancer (CRC); despite this, several mutations--including KRAS, BRAF, and PIK3CA mutations, and HER2 amplification--are associated with the mechanisms underlying the development of resistance to anti-EGFR therapy. The aim of our study was to investigate the frequencies and clinical implications of these...

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Identifiers

PMID: 26991109
DOI: 10.1371/journal.pone.0151865
PMCID: PMC4798471

Genes

KRAS
BRAF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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