Article
Evaluation of High Resolution Melting for MTHFR C677T Genotyping in Congenital Heart Disease.
PloS one - 1 Jan 2016
Wang Ying, Zhang Haiyan, Yue Shuying, Zhang Kun, Wang Hui, Dong Rui, Yang Xiaomeng, Liu Yi, Ma Yanhui
Abstract excerpt
BACKGROUND: High resolution melting (HRM) is a simple, flexible and low-cost mutation screening technique. The methylenetetrahydrofolate reductase (MTHFR) gene encoding a critical enzyme, potentially affects susceptibility to some congenital defects like congenital heart disease (CHD). We evaluate the performance of HRM for genotyping of the MTHFR gene C677T locus in CHD cases and healthy controls of Chinese Han...
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