Article
Association between CASP8 and CASP10 polymorphisms and toxicity outcomes with platinum-based chemotherapy in Chinese patients with non-small cell lung cancer.
The oncologist - 1 Jan 2012
Qian Ji, Qu Hui-Qi, Yang Lixin, Yin Ming, Wang Qiming, Gu Shaohua, Wu Qihan, Zhao Xueying, Wu Wenting, Wu Junjie, Tan Xiaoming, Chen Wenqing, Wang Haijian, Wang Jiucun, Fan Weiwei, Chen Hongyan, Han Baohui, Lu Daru, Wei Qingyi, Jin Li
Abstract excerpt
Caspase-8 and caspase-10 play crucial roles in both cancer development and chemotherapy efficacy. In this study, we aimed to comprehensively assess single nucleotide polymorphisms (SNPs) of the caspase-8 (CASP8) and caspase-10 (CASP10) genes in relation to toxicity outcomes with first-line platinum-based chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). We genotyped 13 tag SNPs of CASP8...
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