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Article

DNA damage signalling barrier, oxidative stress and treatment-relevant DNA repair factor alterations during progression of human prostate cancer.

Molecular oncology - 1 Jun 2016

Kurfurstova Daniela, Bartkova Jirina, Vrtel Radek, Mickova Alena, Burdova Alena, Majera Dusana, Mistrik Martin, Kral Milan, Santer Frederic R, Bouchal Jan, Bartek Jiri

Abstract excerpt

The DNA damage checkpoints provide an anti-cancer barrier in diverse tumour types, however this concept has remained unexplored in prostate cancer (CaP). Furthermore, targeting DNA repair defects by PARP1 inhibitors (PARPi) as a cancer treatment strategy is emerging yet requires suitable predictive biomarkers. To address these issues, we performed immunohistochemical analysis of multiple markers of DNA damage...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26987799
DOI: 10.1016/j.molonc.2016.02.005
PMCID: PMC5423169

Genes

NQO1
ERG
TMPRSS2
ATM
PARP1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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