Article
Activation of ERK/IER3/PP2A-B56γ-positive feedback loop in lung adenocarcinoma by allelic deletion of B56γ gene.
Oncology reports - 1 May 2016
Ito Tomoko, Ozaki Satoru, Chanasong Rachanee, Mizutani Yuki, Oyama Takeru, Sakurai Hiroshi, Matsumoto Isao, Takemura Hirofumi, Kawahara Ei
Abstract excerpt
In order to investigate the involvement of the IER3/PP2A-B56γ/ERK-positive feedback loop, which leads to sustained phosphorylation/activation of ERK in carcinogenesis, we immunohistochemically examined the expression of IER3 and phosphorylated ERK in lung tumor tissues. IER3 was overexpressed in all cases of adenocarcinomas examined, but was not overexpressed in squamous cell carcinomas. Phosphorylated ERK (pERK)...
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