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Article

Mechanical heart valve recipients: anticoagulation in patients with genetic variations of phenprocoumon metabolism.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery - 1 Aug 2013

Brehm Kerstin, Schack Jenny, Heilmann Claudia, Blanke Philipp, Geissler Hans Joachim, Beyersdorf Friedhelm

Abstract excerpt

OBJECTIVES: Oral anticoagulation in mechanical heart valve recipients remains crucial, and vitamin K antagonists (VKA) are still the gold standard. Polymorphisms of vitamin K epoxide oxidase reductase (VKORC) and cytochrome p450 (CYP2C9) were recently found to influence VKA metabolism. We retrosp...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

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Source

Identifiers

PMID: 23423913
DOI: 10.1093/ejcts/ezt002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23423913-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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