Article
Evaluation of new approaches to poliovirus vaccine neurovirulence tests.
Developments in biological standardization - 1 Jan 1996
Wood D J
Abstract excerpt
Transgenic mice that express the human receptor for poliovirus and mutant analysis by PCR followed by restriction enzyme cleavage (MAPREC) are two new approaches to poliovirus vaccine neurovirulence testing. This review assesses the validity and current status of these tests. Both approaches requ...
Topics
- Animal Testing Alternatives
- Animals
- Humans
- Mice
- Mice, Transgenic
- Mutation
- Poliovirus Vaccine, Inactivated
- Poliovirus Vaccine, Oral
- Polymerase Chain Reaction
- Primates
- Quality Control
- Receptors, Virus
- Virulence