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Article

Enterovirus A71 Induces Neurological Diseases and Dynamic Variants in Oral Infection of Human SCARB2-Transgenic Weaned Mice.

Journal of virology - 13 Oct 2021

Lin Jing-Yi, Weng Kuo-Feng, Chang Chih-Kuang, Gong Yu-Nong, Huang Guo-Jen, Lee Hui-Lan, Chen Yen-Cheng, Huang Chien-Chih, Lu Jia-Ying, Huang Peng-Nien, Chiang Huan-Jung, Chen Che-Min, Shih Shin-Ru

Abstract excerpt

Enterovirus A71 (EV-A71) and many members of the Picornaviridae family are neurotropic pathogens of global concern. These viruses are primarily transmitted through the fecal-oral route, and thus suitable animal models of oral infection are needed to investigate viral pathogenesis. An animal model of oral infection was developed using transgenic mice expressing human SCARB2 (hSCARB2 Tg), murine-adapted EV-A71/MP4...

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Identifiers

PMID: 34379497
DOI: 10.1128/JVI.00897-21
PMCID: PMC8513470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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