Article
Serum IL-18 level, clinical symptoms and IL-18-607A/C polymorphism among chronic patients with schizophrenia in a Chinese Han population.
Psychoneuroendocrinology - 1 Jun 2016
Zhang Xiang Yang, Tan Yun-Long, Chen Da-Chun, Tan Shu-Ping, Malouta Michelle Z, Bernard Jared D, Combs Jessica L, Bhatti Sarai, Davis Michael C, Kosten Thomas R, Soares Jair C
Abstract excerpt
Literature suggests that alterations in the inflammatory and immune systems are involved in the pathogenesis of schizophrenia. Specifically, patients diagnosed with schizophrenia exhibit increased IL-18, a pleiotropic proinflammatory cytokine in type 1 T-helper (Th1) responses. The functional 607A/C promoter polymorphism of the IL-18 gene is also associated with the psychopathology of this disorder. However, no...
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